CRYSTAL STRUCTURE OF A HUMAN IGM RHEUMATOID FACTOR FAB IN COMPLEX WITH ITS AUTOANTIGEN IGG FC


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1ADQ
Accession Number 3DIEP0265
IEDB ID 135616
Epitope Sequence L14; M15; I16; S17; R18; N147; G148; S187; M191; H196; N197; H198; Y199; Q201; S203
Starting Position14-18,147-148,187,191,196-199,201,203
Ending Position203
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen Chain A; Crystal Structure Of A Human Igm Rheumatoid Factor Fab In Complex With Its Autoantigen Igg Fc Homo sapiens
PDB CategoryCOMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN)
Keyword COMPLEX (IMMUNOGLOBULIN/AUTOANTIGEN); RHEUMATOID FACTOR AUTO-ANTIBODY COMPLEX
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainA
Contact Area for Antigen 705.2
Contact Area for Antibody753.7
CommentsEpitope specific RF-AN Fab was crystallized with the Fc fragment of human IgG4 paraprotein Rea.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
3.15
R-Value
0.225
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 160.35 α = 90
b = 81.95 β = 98.27
c = 64.24 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Homo sapiens
Common Namehuman
Taxonomic ID9606
Source Organism Homo sapiens
Common Namehuman
Taxonomic ID9606
Source Organism Homo sapiens
Common Namehuman
Taxonomic ID9606
Entity ID3


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Ligand L-peptide linking