COMPLEX BETWEEN HUMAN T-CELL RECEPTOR; VIRAL PEPTIDE (TAX); AND HLA-A 0201


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1AO7
Accession Number 3DIEP0304
IEDB ID 37257
Epitope Sequence LLFGYPVYV
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen LLFGYPVYV transcriptional activator Tax (11-19) Human T-lymphotropic virus 1
PDB CategoryCOMPLEX (MHC/VIRAL PEPTIDE/RECEPTOR)
Keyword CLASS I MHC; T-CELL RECEPTOR; VIRAL PEPTIDE; COMPLEX (MHC/VIRAL PEPTIDE/RECEPTOR; COMPLEX (MHC/VIRAL PEPTIDE/RECEPTOR) COMPLEX
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain D
Antigen PDB ChainC
CommentsA ternary complex containing a soluble A6 ??TCR with the Tax peptide bound to HLA-A2 was crystallized and the structure determined. Clear electron density was observed for the TCR-MHC/Epitope interface as well as for the ?1; ?2; ?2-m MHC domains and the V?; V? TCR domains. The MHC ?3 domain is disordered. The final model includes MHC residues 1-274; ?2-m residues 0-99; 1-9 epitope residues and residues 1-122 TCR?; 3-246 TCR?; except for loops 131-144; 180-189 and 220-229.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.6
R-Value
0.245
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 229.3 α = 90
b = 49.5 β = 89.6
c = 96 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION