CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX


Tab-View Sample


MHC-Binding
Epitope  
   
Complex PDB ID 1B0G
Accession Number 3DIEP0578
IEDB ID 2999
Epitope Sequence ALWGFFPVL
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen Purified MHC - X-ray crystallography Structure (crystal; NMR; etc.)
PDB CategoryHISTOCOMPATIBILITY ANTIGEN
Keyword CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainC
CommentsThe crystal structure of HLA-A*0201 complexed with the epitope p1049 was determined using the molecular replacement method. The epitope complexed with A2 is recognized by TCR AHIII12.2 from a CD8+ CTL clone derived from a C57BL/6 mouse injected with the human lymphoblastoid cell line JY. There are two molecules in the crystallographic asymmetric unit. PDB chains for each complex are: Complex I : MHC a-chain: A; ß2-m chain: B; epitope chain: C. Complex II : MHC a-chain: d; ß2-m chain: e; epitope chain: F. Epitope main chain density is relatively weak near residue P5. This may indicate some flexibility around the middle of the peptide.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.5
R-Value
0.26
Space Group
P 1
Unit Cell
Length(Å) Angle(°)
a = 50.09 α = 81.98
b = 62.89 β = 76.18
c = 74.68 γ = 77.86



Fatal error: Uncaught Error: Call to undefined function mysql_connect() in /opt/lampp/htdocs/sedb/htdocs/tabview.php:6804 Stack trace: #0 {main} thrown in /opt/lampp/htdocs/sedb/htdocs/tabview.php on line 6804
Source Information  
Structure Determination Method X-RAY DIFFRACTION