VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1BJ1
Accession Number 3DIEP0009
IEDB ID 92221
Epitope Sequence W: F43; Y47 V: Y71; K74; Q105; I106; M107; R108; I109; K110; H112; Q113; G114; Q115; H116; I117; G118; E119; M120
Starting Position43,47,71,74,105
Ending Position110,112-120
Epitope Type Discontinious Epitope

Assay Information  
Assay Antigen VEGF VEGF Homo sapiens
PDB CategoryCOMPLEX (ANTIBODY/ANTIGEN)
Keyword COMPLEX (ANTIBODY/ANTIGEN); ANGIOGENIC FACTOR
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainV
Contact Area for Antigen 900
Contact Area for Antibody841.5
CommentsEpitope and paratope are the same as in the structure [PDB: 1CZ8]. Antigen doesn t change conformation upon antibody binding according to comparison with unbound antigen [PDB: 1VPF].

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.4
R-Value
0.196
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 89.86 α = 90
b = 66.98 β = 94.27
c = 140.51 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION

Ligand
Ligand NameSULFATE ION
Chem Name SO4




Sequence
Protein Name
SULFATE ION
Poly type
polypeptide(L)
Sequence status
Complete

Err:Conn