IGG FAB (HUMAN IGG1; KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 1CLY
Accession Number 3DIEP0257
IEDB ID 76789
Epitope Sequence Lewis Y (Ley) tetrasaccharides
Starting Position228
Ending Position232
Epitope Type Non peptidic

Assay Information  
Assay Antigen Not available
PDB CategoryIMMUNOGLOBULIN
Keyword IMMUNOGLOBULIN; IMMUNOGLOBULIN C REGION; GLYCOPROTEIN; ANTIB
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antigen PDB ChainH
CommentsThe epitope residues in PDB are (FUC); (GAL); (NAG); (FUC); and (NON). Where; FUC is FUCOSE (C6 H12 O5 CC1OC(O)C(O)C(O)C1O). GAL is D-GALACTOSE (C6H12O6 OCC1OC(O)C(O)C(O)C1O). NAG is N-ACETYL-D-GLUCOSAMINE ( C8 H15 N O6 CC(=O)NC1C(O)OC(CO)C(O)C1O). NON is METHYL NONANOATE (ESTER) ( C10 H20 O2 CCCCCCCCC(=O)OC). This structure is conformationally identical to the structure of the same epitope in complex with mouse BR96 [PDB:1CLZ] with slightly different epitope-Fab contacts.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.5
R-Value
0.238
Space Group
P 43 21 2
Unit Cell
Length(Å) Angle(°)
a = 81.7 α = 90
b = 81.7 β = 90
c = 166.3 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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