IGG FAB (IGG3; KAPPA) FRAGMENT (MBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 1CLZ
Accession Number 3DIEP0178
IEDB ID 76789
Epitope Sequence Lewis Y (Ley) tetrasaccharide
Starting Position232
Ending Position236
Epitope Type Non peptidic

Assay Information  
Assay Antigen Lewis Y (Ley) tetrasaccharide Homo sapiens
PDB CategoryIMMUNOGLOBULIN
Keyword IMMUNOGLOBULIN C REGION; GLYCOPROTEIN; TRANSMEMBRANE
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain L
Antigen PDB ChainH
CommentsThe epitope residues in PDB are (FUC); (GAL); (NAG); (FUC); and (NON). Where; FUC is FUCOSE (C6 H12 O5 CC1OC(O)C(O)C(O)C1O). GAL is D-GALACTOSE (C6H12O6 OCC1OC(O)C(O)C(O)C1O). NAG is N-ACETYL-D-GLUCOSAMINE ( C8 H15 N O6 CC(=O)NC1C(O)OC(CO)C(O)C1O). NON is METHYL NONANOATE (ESTER) ( C10 H20 O2 CCCCCCCCC(=O)OC). This structure is conformationally identical to the structure of the same epitope in complex with the human chimeric BR96 [PDB:1CLY] with slightly different epitope-Fab contacts.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.8
R-Value
0.197
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 69.4 α = 90
b = 84.9 β = 90
c = 86.8 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID2


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Ligand non-polymer