X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB


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MHC-Binding
Epitope  
   
Complex PDB ID 1D5X
Accession Number 3DIEP0460
IEDB ID 94973
Epitope Sequence XRXXX
Starting Position803
Ending Position808
Epitope Type Linear Epitope

Assay Information  
Assay Antigen Purified MHC - X-ray crystallography Structure (crystal; NMR; etc.)
PDB CategoryIMMUNE SYSTEM
Keyword COMPLEX (MHC CLASS II/SUPERANTIGEN); IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainD
CommentsThe crystal structure contains the MHC/epitope complex bound to the superantigen (SAG) staphylococcal enterotoxin B (SEB). SAG PDB chain is D. The SAG was included in the complex as a vehicle to form crystals of MHC with novel compounds that diffract well. Clear electron density is observed for the MHC residues except for a loop consisting of residues B:105-112 and for the SAG molecule for a loop consisting of residues 99-108.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.45
R-Value
0.237
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 90.838 α = 90
b = 104.252 β = 90
c = 107.818 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION