Crystal Structure Determination Of HLA A2 Complexed to Peptide GP2 with the substitution (I2L/V5L/L9V)


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MHC-Binding
Epitope  
   
Complex PDB ID 1EEY
Accession Number 3DIEP0489
IEDB ID 95099
Epitope Sequence ILSALVGIL
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen "Purified MHC - X-ray crystallography Structure (crystal; NMR; etc.)"
PDB CategoryIMMUNE SYSTEM
Keyword major histicompatibility complex; peptide binding; crystallography; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainC
CommentsThere are two molecules in the crystallographic asymmetric unit. PDB chains for each complex are: Complex 1 : MHC ?-chain: A; ?2-m chain: B; epitope chain: C. Complex 2 : MHC ?-chain: D; ?2-m chain: E; epitope chain: F. There is clear electron density for the peptide terminal residues in both molecules. There are some differences in the electron density of the peptides in the two molecules; but they do not affect the orientations of the peptide. There is a break in the electron density at residue P6 and P7 in both of the molecules. The orientation of P6 cannot be interpreted in either molecule.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.25
R-Value
0.248
Space Group
P 1
Unit Cell
Length(Å) Angle(°)
a = 49.95 α = 82.07
b = 62.93 β = 76.5
c = 74.65 γ = 78.04



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Source Information  
Structure Determination Method X-RAY DIFFRACTION