FAB FRAGMENT OF NEUTRALISING MONOCLONAL ANTIBODY 4C4 COMPLEXED WITH G-H LOOP FROM FMDV.


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1EJO
Accession Number 3DIEP0031
IEDB ID 79128
Epitope Sequence YTASARGDLAHVTAT
Starting Position3136
Ending Position3147
Epitope Type Linear Epitope

Assay Information  
Assay Antigen P: Y3136; T3137; T3138; S3139; T3140; R3141; G3142; D3143; L3144; A3145; H3146; V3147
PDB CategoryIMMUNE SYSTEM
Keyword FMDV; antigenic-antibody interactions; RGD motif; G-H loop of VP1.; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainP
Contact Area for Antigen 812.6
Contact Area for Antibody600.5
CommentsThe bound peptide adopts a compact fold with a nearly cyclic conformation and a disposition of the receptor-recognition motif Arg-Gly-Asp (residues 3141-3143) that is closely related to the previously determined structure for the viral loop; as part of the intact virion. Well-defined water molecules appear play a major role in the stabilization of the peptide conformation and its interactions with the Fab.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.3
R-Value
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 48.18 α = 90
b = 69.328 β = 90
c = 146.539 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID2


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Ligand non-polymer