INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1EO8
Accession Number 3DIEP0032
IEDB ID 103766
Epitope Sequence KLDIDPHVFRKFGD
Starting Position66,75-76,78-79,90
Ending Position91,94-95
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen QDLPGNDNSTATLCL GHHAVPNGTLVKTIT DDQIEVTNATELVQS.Hemagglutinin (17-521) Influenza A virus (A/X-31(H3N2))
PDB CategoryViral protein/Immune system
Keyword COMPLEX (HEMAGGLUTININ/IMMMUNOGLOBULIN); HEMAGGLUTININ; IMMUNOGLOBULIN; VIRAL PROTEIN; IMMUNE SYSTEM COMPLEX; Viral protein/Immune system COMPLEX
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainA
Contact Area for Antigen 760.5
Contact Area for Antibody769
CommentsDetails of antigen-antibody contacts are not provided in the paper. There is no change in the overall X31 HA structure upon complex formation as compared either to the uncomplexed HA molecule [PDB: 1HGF] or to X31 HA in the complex with the HC45 Fab [PDB: 1QFU]. However; there are significant local changes such as movements of the residues A: D63; K92.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.8
R-Value
Space Group
P 3 2 1
Unit Cell
Length(Å) Angle(°)
a = 138.15 α = 90
b = 138.15 β = 90
c = 129.5 γ = 120



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Influenza A virus (A/X-31(H3N2))
Taxonomic ID132504
Source Organism Influenza A virus (A/X-31(H3N2))
Taxonomic ID132504
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID4


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Ligand non-polymer