CRYSTAL STRUCTURE OF THE VON WILLEBRAND FACTOR A3 DOMAIN IN COMPLEX WITH A FAB FRAGMENT OF IGG RU5 THAT INHIBITS COLLAGEN BINDING


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1FE8
Accession Number 3DIEP0209
IEDB ID 131327
Epitope Sequence P1725; R1726; L1727; T1728; Q1729; P1744; W1745; N1746; V1747; V1748; P1749; E1750; K1751; A1752; H1753; L1754; L1755; S1756; L1757; V1758; D1759; V1760; M1785; H1786; G1787; A1788; R1789
Starting Position1725-1729,1744-1760,1785
Ending Position1789
Epitope Type Discontiunous Epitope

Assay Information  
Assay Antigen APDCSQPLDVILLLD GSSSFPASYFDEMKS FAKAFISKANIGPRL TQVSV... + SCM(M1785) von Willebrand factor (1683-1874) Homo sapiens
PDB CategoryIMMUNE SYSTEM
Keyword Collagen binding; conformational changes; epitope; von Willebrand factor A-type domain; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainA
Contact Area for Antigen 1002.2
Contact Area for Antibody916.8

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.03
R-Value
0.229
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 121.8 α = 90
b = 183.6 β = 116.2
c = 131.8 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID3


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Ligand non-polymer