LYME DISEASE ANTIGEN OSPA IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB LA-2


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 1FJ1
Accession Number 3DIEP0040
IEDB ID 116891
Epitope Sequence F: S206; S207; A208; A209; T210; K211; K212; T213; A214; A215; T226; V227; N228; S229; K230; K231; D249; S250; N251; G252; T253
Starting Position2206-215,226-231,249
Ending Position253
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen Outer surface protein A Outer surface protein A Borrelia burgdorferi
PDB CategoryIMMUNE SYSTEM
Keyword OSPA; LYME DISEASE; ANTIBODY FAB FRAGMENT; NEUTRALIZING EPITOPE; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antibody Chain 2 PDB ChainB
Antigen PDB ChainF
Contact Area for Antigen 872.1
Contact Area for Antibody755.1
CommentsParatope residues and antigen-antibody contacts are not provided in the paper. There is only mention that the interactions between OspA and LA-2 include 8 direct H-bonds; 4 solvent-bridged hydrogen bonds; and 3 ion pairs. The crystal structure contains two identical complexes in the asymmetric unit. Mab 336 epitope seems do not overlap with LA-2 epitope. Both are located in C-terminal region of OspA. Mab 184.1 epitope is located in the N-terminal of OspA [PDB: 1OSP].

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.68
R-Value
Space Group
P 21 21 2
Unit Cell
Length(Å) Angle(°)
a = 100.079 α = 90
b = 129.462 β = 90
c = 143.738 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID2


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Ligand non-polymer