CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL RECEPTOR; INFLUENZA HA ANTIGEN PEPTIDE; AND MHC CLASS II MOLECULE; HLA-DR1


Tab-View Sample


T-Cell Epitope
Epitope  
   
Complex PDB ID 1FYT
Accession Number 3DIEP0275
IEDB ID 48237
Epitope Sequence PKYVKQNTLKLAT
Starting Position306
Ending Position318
Epitope Type Linear Epitope

Assay Information  
Assay Antigen PKYVKQNTLKLAT Hemagglutinin precursor (322-334) Influenza A virus (A/Aichi/2/1968(H3N2))
PDB CategoryIMMUNE SYSTEM
Keyword protein-protein complex; immunoglobulin fold; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain D
Antigen PDB ChainC
CommentsIn total; 7 of the 15 MHCII positions contacted to TCR in this complex are contacted in the D10/Tax/I-Ak complex [PDB: 1D9K]. The TCR-pMHC binding mode is close to that observed in the human B7 TCR/Tax/HLA-A2 complex [PDB: 1BD2].

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.6
R-Value
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 142.902 α = 90
b = 73.439 β = 108.23
c = 122.428 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION