A FUNCTIONAL HOT SPOT FOR ANTIGEN RECOGNITION IN A SUPERAGONIST TCR/MHC COMPLEX


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1G6R
Accession Number 3DIEP0296
IEDB ID 58773
Epitope Sequence SIYRYYGL
Starting Position1
Ending Position8
Epitope Type Linear Epitope

Assay Information  
Assay Antigen SIYRYYGL
PDB CategoryIMMUNE SYSTEM
Keyword T CELL ANTIGEN RECEPTOR; MAJOR HISTOCOMPATIBILITY COMPLEX; SUPERAGONIST; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainP
CommentsThe crystal structure of the ternary complex of the 2C TCR with the epitope bound to H-2Kb was determined. There are two independent complexes in the crystallographic asymmetric unit. PDB chains for each complex are: Complex I : MHC chain: H; MHC ?2-microglobulin chain: L; epitope chain: P; TCR ?-chain: A; MHC ?-chain: B. Complex II : MHC chain: I; MHC ?2-microglobulin chain: M; epitope chain: Q; TCR ?-chain: C; MHC ?-chain: D. In one of the complexes the electron density is highly disordered for the TCR.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.8
R-Value
Space Group
P 21 21 2
Unit Cell
Length(Å) Angle(°)
a = 297.71 α = 90
b = 94.57 β = 90
c = 84.89 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION