Murine Alloreactive ScFv TCR-Peptide-MHC Class I Molecule Complex


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1KJ2
Accession Number 3DIEP0306
IEDB ID 34055
Epitope Sequence KVITFIDL
Starting Position1
Ending Position8
Epitope Type Linear Epitope

Assay Information  
Assay Antigen KVITFIDL GTP binding protein 1 Mus musculus"
PDB CategoryIMMUNE SYSTEM
Keyword T CELL RECEPTOR; CLASS I MHC; H-2KB; TCR-PMHC COMPLEX; ALLOGENEIC; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainP
CommentsThe V module of the KB5-C20 TCR was produced in myeloma cells. There are two molecules in the crystallographic asymmetric unit. PDB chains for each complex are: Complex I MHC ?-chain: H; ?2-m chain: L; epitope chain: P; TCR ?-chain: A; TCR ?-chain: B. Complex II: MHC ?-chain: I; ?2-m chain: M; epitope chain: Q; TCR ?-chain: D; TCR ?-chain: E. The two complexes differ only by a 6 degrees rotation in the ?3/?2-m membrane-proximal domains.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.71
R-Value
0.219
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 89.2 α = 90
b = 77.92 β = 108.23
c = 132.96 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION