Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 1KXT
Accession Number 3DIEP0247
IEDB ID 121101
Epitope Sequence L252; G253; G254; K272; A275; K276; T279; W284; S285; G286; E287; K288; Y291; N294; G298; W299; G300; G324; S325; S326; G428
Starting Position252-254,272,275-276,279,284-288,291,294,298-300,324-326,428
Ending Position428
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen Pancreatic alpha-amylase precursor Pancreatic alpha-amylase precursor Sus scrofa
PDB CategoryHYDROLASE; IMMUNE SYSTEM
Keyword ALPHA 8 BETA 8; BETA BARREL; HYDROLASE; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antibody Chain 2 PDB ChainB
Antigen PDB ChainB
Contact Area for Antigen 810.3
Contact Area for Antibody805.2
CommentsAMB7 VHH binds the antigen outside the catalytic site and inhibits only partially the amylase activity. The crystal contains three complexes in the asymmetric unit.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2
R-Value
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 52.78 α = 90
b = 286.85 β = 93.73
c = 65.98 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Sus scrofa
Common Namepig
Taxonomic ID9823
Entity ID1


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Ligand non-polymer