Xenoreactive complex AHIII 12.2 TCR bound to p1049/HLA-A2.1


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1LP9
Accession Number 3DIEP0309
IEDB ID 2999
Epitope Sequence ALWGFFPVL
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen ALWGFFPVL chromosome 15 open reading frame 24 Homo sapiens
PDB CategoryIMMUNE SYSTEM
Keyword Immunoregulatory complex; Class I MHC:TCR co-crystal; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain E
Antigen PDB ChainC
CommentsThe ? and ? chains of the soluble AHIII 12.2 TCR were produced in E. coli as inclusion bodies and refolded to the native state in vitro. There are two molecules in the crystallographic asymmetric unit. PDB chains for each complex are: Complex I: MHC ?-chain: A; ?2-m chain: B; epitope chain: C; TCR ?-chain: E; TCR ?-chain: F. Complex II : MHC ?-chain: H; ?2-m chain: I; epitope chain: J; TCR ?-chain: L; TCR ?-chain: M. The two complexes are nearly identical. They are in the same orientation such that a simple lateral translation relates the two copies.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2
R-Value
0.22058
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 93.708 α = 90
b = 84.469 β = 92.13
c = 121.336 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION