FAB FRAGMENT OF PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL-D-ALANINE


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B-Cell Epitope
Epitope  
   
Complex PDB ID 2BMK
Accession Number 3DIEP0175
IEDB ID 76942
Epitope Sequence PPL-D-alanine
Starting Position1215
Ending Position1217
Epitope Type Non peptidic

Assay Information  
Assay Antigen PPL-D-alanine
PDB CategoryIMMUNE SYSTEM
Keyword CATALYTIC ANTIBODY; TRANSAMINATION; PYRIDOXAL-PHOSPHATE; HAPTEN; PHOSPHOPYRIDOXYL-L-LYSINE; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antibody Chain 2 PDB ChainB
Antigen PDB ChainB
Contact Area for Antigen 382
Contact Area for Antibody201.9
CommentsTyrH100B has different conformations in two molecules of the asymmetric unit in comparison with the structure of 15A9 Fab in the complex with its immunogen PPL-N(e)-acetyl-L-lysine [PDB: 1WCB]. Therefore; two complexes have been curated.The paper provides comparison of this structure [PDB: 2BMK] with the structure of the chicken mitochondrial L-aspartate aminotransferase (mAspAT) in complex with the PLP-L-aspartate ketamine intermidiate [PDB: 1MAP] and D-amino acid aminotransferase from Bacillus species YM-1 (DaAT) in complex with PPL-D-alanine [PDB: 3DAA]. The PLP moiety is bound in a quite similar way in all three structures.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.3
R-Value
0.2097
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 63.152 α = 90
b = 81.152 β = 90.35
c = 79.331 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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