STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES


Tab-View Sample


T-Cell Epitope
Epitope  
   
Complex PDB ID 2BNQ
Accession Number 3DIEP0311
IEDB ID 59283
Epitope Sequence SLLMWITQV
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen SLLMWITQV
PDB CategoryIMMUNE SYSTEM/RECEPTOR
Keyword IMMUNE SYSTEM/RECEPTOR; IMMUNE SYSTEM/RECEPTOR/COMPLEX; TCR; MHC; IMMUNODOMINANCE; FLU; COMPLEX; PEPTIDE; TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL; POLYMORPHISM; T-CELL; RECEPTOR; SUPERAGONIST PEPTIDE T-CELL VACCINES
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain D
Antigen PDB ChainC
CommentsThe 1G4 TCR was purified from 1G4 CTL lines derived from melanoma patients and shown to be specific for the epitope NY-ESO-1-(157-165). The TCR was refolded and purified from E. coli derived inclusion bodies.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
1.7
R-Value
0.226
Space Group
P 1 21 1
Unit Cell
Length(Å) Angle(°)
a = 72.563 α = 90
b = 62.49 β = 105.34
c = 116.955 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION