Cofactor-containing antibodies: Crystal structure of the original yellow antibody


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B-Cell Epitope
Epitope  
   
Complex PDB ID 2FL5
Accession Number 3DIEP0255
IEDB ID 76940
Epitope Sequence Riboflavin
Starting Position202
Ending Position202
Epitope Type Non peptidic

Assay Information  
Assay Antigen Riboflavin Riboflavin Homo sapiens
PDB CategoryIMMUNE SYSTEM
Keyword human antibody; riboflavin-binding; cofactor; multiple myeloma; IGGGAR; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain L
Antibody Chain 2 PDB ChainH
Antigen PDB ChainB
CommentsBinding of riboflavin occurs in a narrow cleft; with the vitamin isoalloxazine ring stacked between the parallel aromatic groups of TyrH100A; TyrH33; and PheH58. Riboflavin makes the following hydrogen bonds with Fab (Fig. 4; to be curated): O4 - TyrH100A ND2; O2 - GluH56 OE1 and OE2; O5 - ArgH52 NH1 and NH2. In the crystallographic asymmetric unit; GluH85 in Fab molecules of complexes C and D hydrogen bonds to O5 of riboflavin of complexes A and B; respectively. No water-mediated hydrogen bonds are formed between riboflavin and Fab.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
3
R-Value
0.24
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 100.592 α = 90
b = 111.105 β = 90
c = 188.454 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Homo sapiens
Common Namehuman
Taxonomic ID9606
Source Organism Homo sapiens
Common Namehuman
Taxonomic ID9606
Entity ID2


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Ligand non-polymer