Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus.

Tab-View Sample

B-Cell Epitope
Complex PDB ID 2R6P
Accession Number 3DIEP0220
IEDB ID 132955
Epitope Sequence K304; F305; K306; V307; V308; K309; I310; Q312; P336; K361; N366
Starting Position304-312,336,361,366
Ending Position366
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen polyprotein Dengue virus 2 Thailand/16681/84
PDB CategoryVirus/Immune System
Keyword Fab; dengue; virus; neutralization; Virus/Immune System COMPLEX; icosahedral virus
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain D
Antibody Chain 2 PDB ChainE
Antigen PDB ChainA
CommentsThe epitope on the domain III is completely exposed and its associated domain II has a fusion tip pointing toward the viral lipid envelope. The structure contains coordinates of only C&alpha atoms; therefore the contacts cannot be calculated.

Experimental Details
Experimental Method
Agregation state
Nominal defox
Microscope Model

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Source Information  
Structure Determination Method ELECTRON MICROSCOPY

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