CRYSTAL STRUCTURE OF THE MAJOR GRASS POLLEN ALLERGEN PHL P 2 IN COMPLEX WITH ITS SPECIFIC IGE-FAB


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B-Cell Epitope
Epitope  
   
Complex PDB ID 2VXQ
Accession Number 3DIEP0263
IEDB ID 103763
Epitope Sequence E56; E58; D60; H62; D65; E66; W67; A69; N91; R93; F94; L95; G99; M100; K101; N102; V103; F104; D105; D106; P120
Starting Position56,58,60,62,65-67,69,91,93-95,99-106,120
Ending Position120
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen Pollen allergen Phl p 2 Phleum pratense
PDB CategoryALLERGEN
Keyword RECEPTOR; SECRETED; RPHL P 2; ALLERGEN; ALLERGEN/IGE FAB COMPLEX; RECOMBINANT GRASS POLLEN ALLERGEN
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainA
Contact Area for Antigen 821.3
Contact Area for Antibody776.9
CommentsThe epitope-specific huMab2 Fab recognizes a discontinuous epitope which consists of a four-stranded anti-parallel beta-sheet formed by 21 residues. The epitopic residues belong to strands ß3 (E30; E32; D34; H36); ß4 (A43); ß6 (N65; R67; F68; L69) and ß7 (M74;K75; N76; V77; F78); and residues D39; E40; W41; G73; D79; D80 in the loops joining the strands and the C-terminal residue P94.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
1.9
R-Value
0.179
Space Group
P 42 21 2
Unit Cell
Length(Å) Angle(°)
a = 105.437 α = 90
b = 105.437 β = 90
c = 110.225 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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