Crystal structure of HLA-B*4402 in complex with the R5A/F7A double mutant of a self-peptide derived from DPA*0201


Tab-View Sample


MHC-Binding
Epitope  
   
Complex PDB ID 3L3K
Accession Number 3DIEP0568
IEDB ID 134906
Epitope Sequence EEFGAAASF
Starting Position1
Ending Position9
Epitope Type Linear Epitope

Assay Information  
Assay Antigen Purified MHC - X-ray crystallography Structure (crystal; NMR; etc.)
PDB CategoryIMMUNE SYSTEM
Keyword Immunoglobulin domain; Immune response; Major Histocompatibility Complex Class I; MHC-I peptide complex; altered peptide ligand; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainC
CommentsThe paper describes X-ray structures of the B44-DPa with five alanine-scan mutants of the peptide (F3A; R5A; F7A; F3AR5A; and R5AF7A) (Fig. 1; Fig. S1; and Table S1). All structures were solved in the same space group; were isomorphous to each other; and the peptides are free from crystal contacts. Thus any conformational changes observed can be attributed to the specific mutation within the peptide.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.6
R-Value
0.21734
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 50.581 α = 90
b = 82.084 β = 90
c = 109.23 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION