Crystal Structure of Fab 2D1 in Complex with the 1918 Influenza Virus Hemagglutinin


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 3LZF
Accession Number 3DIEP0264
IEDB ID 137355
Epitope Sequence S138; S139; P141; N142; K171; G172; S173; S174; Y175; P176; K177; S179; K180; S181; V183; N211; E259; T261
Starting Position138-139,141-142,171-177,179-181,183,211,259,261
Ending Position261
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen hemagglutinin Influenza A virus (A/South Carolina/1/1918(H1N1))
PDB CategoryVIRAL PROTEIN/IMMUNE SYSTEM
Keyword hemagglutinin; Fab; neutralizing antibodies; antibody; pandemic flu; swine flu; Envelope protein; Fusion protein; Glycoprotein; antigen; Virion; VIRAL PROTEIN-IMMUNE SYSTEM complex
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainA
Contact Area for Antigen 913
Contact Area for Antibody888.8
CommentsHeavy chain CDR1 adopts an unusual; open loop conformation it makes few contacts with HA and is likely very flexible in solution. The heavy and light chains recognize separate; nearly discontinuous surfaces on HA; with a small cavity being formed at the junction between VH; VL; and the HA.


Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.8
R-Value
0.23154
Space Group
P 3 2 1
Unit Cell
Length(Å) Angle(°)
a = 161.745 α = 90
b = 161.745 β = 90
c = 143.473 γ = 120



Source Information  
Structure Determination Method X-RAY DIFFRACTION
Host OrganismTrichoplusia ni
Host Organism StrainBTI-TN-5B1-4
Host Taxonomic ID 7111
Host OrganismTrichoplusia ni
Host Organism StrainBTI-TN-5B1-4
Host Taxonomic ID 7111
Host OrganismHomo sapiens
Host Taxonomic ID 9606
Host Organ kidney
PlasmidpEE6.4
  
Host OrganismHomo sapiens
Host Taxonomic ID 9606
Host Organ kidney
PlasmidpEE12.4
  


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