1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1CE1
Accession Number 3DIEP0015
IEDB ID 107874
Epitope Sequence GTSSPSAD
Starting Position1
Ending Position7
Epitope Type Linear Epitope

Assay Information  
Assay Antigen GTSSPSAD
PDB CategoryANTIBODY
Keyword THERAPEUTIC; ANTIBODY; CD52
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainP
Contact Area for Antigen 517.5
Contact Area for Antibody349.8
CommentsThe antibody was expressed in CHO cells and was obtained from the culture supernatant. It was then purified by affinity chromatography. The Fab fragment was prepared by digestion. In the structure; there was clear electron density for all the peptide residues.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
1.9
R-Value
0.22
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 54.846 α = 90
b = 60.672 β = 89.72
c = 152.908 γ = 89.85


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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