Convergence of catalytic antibody and terpene cyclase mechanisms: polyene cyclization directed by carbocation-pi interactions


Tab-View Sample


B-Cell Epitope
Epitope  
   
Complex PDB ID 1CF8
Accession Number 3DIEP0016
IEDB ID Not available in IEDB.
Epitope Sequence (HAZ) 4-{4-[2-(1A;7A-Dimethyl-4-Oxy-Octahydro-1-Oxa-4-Aza-Cyclopropa[A]Naphthalen-4-yl) -Acetylamino]-Phen
Starting Position800
Ending Position800
Epitope Type Non peptidic

Assay Information  
Assay Antigen Not available
PDB CategoryCATALYTIC ANTIBODY
Keyword CATALYTIC ANTIBODY; TERPENOID SYNTHASE; CARBOCATION; CYCLIZATION CASCADE
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain H
Antibody Chain 2 PDB ChainL
Antigen PDB ChainH
CommentsNot available

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.7
R-Value
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 101.3 α = 90
b = 70.3 β = 114.2
c = 69.6 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Source Organism Mus musculus
Common Namehouse mouse
Taxonomic ID10090
Entity ID2

Ligand non-polymer
Ligand NameCADMIUM ION
Chem Name CD
Ligand Name4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID
Chem Name HAZ




Sequence
Protein Name
4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID
Poly type
polypeptide(L)
Sequence status
Complete

Err:Conn