CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1D9K
Accession Number 3DIEP0291
IEDB ID 83218
Epitope Sequence HRGAIEWEGIESG
Starting Position134
Ending Position146
Epitope Type Linear Epitope

Assay Information  
Assay Antigen HRGAIEWEGIESG Ovotransferrin precursor (Conalbumin) (Serum transferrin) (Allergen Gal d 3) (Allergen Gal d III) Gallus gallus
PDB CategoryIMMUNE SYSTEM
Keyword T-CELL RECEPTOR; MHC CLASS II; D10; I-AK; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainP
CommentsThe crystal structure contains the MHC/epitope complex bound to V module of TCR D10; derived from AKR/J (H-2k) mouse T cell clone D10.G4. There are two complexes in the crystallographic asymmetric unit; related to each other by a 115 degree rotation. PDB chains for each complex are: Complex I: MHC ?-chain: C; MHC ?-chain: D; epitope chain: P; TCR ?-chain: A; TCR ?-chain: B; Complex II: MHC ?-chain: G; MHC ?-chain: H; epitope chain: Q; TCR ?-chain: E; TCR ?-chain: F. The two complexes are very similar and only complex I is discussed in the analysis. The final model includes residues 1-182 and 2-190 of MHC ? and ? chains; respectively; all 16 epitope residues and residues 2-117; 3-116 of TCR V? and V? domains; respectively.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
3.2
R-Value
0.07
Space Group
P 21 21 2
Unit Cell
Length(Å) Angle(°)
a = 97.6 α = 90
b = 345.3 β = 90
c = 97.7 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION