Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor; Influenza HA Antigen Peptide; and MHC Class II Molecule; HLA-DR4


Tab-View Sample


T-Cell Epitope
Epitope  
   
Complex PDB ID 1J8H
Accession Number 3DIEP0276
IEDB ID 48237
Epitope Sequence PKYVKQNTLKLAT
Starting Position306
Ending Position318
Epitope Type Linear Epitope

Assay Information  
Assay Antigen PKYVKQNTLKLAT Hemagglutinin precursor (322-334) Influenza A virus (A/Aichi/2/1968(H3N2))
PDB CategoryIMMUNE SYSTEM
Keyword protein-protein complex; immunoglobulin fold; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain D
Antigen PDB ChainC
CommentsThis structure is very similar to the structure of the TCR HA1.7/DR1/HA complex [PDB: 1FYT]. Only small conformational differences are observed in the polypeptide mainchain of the HA peptide and the MHC molecule.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.4
R-Value
Space Group
C 1 2 1
Unit Cell
Length(Å) Angle(°)
a = 143.753 α = 90
b = 73.317 β = 108.52
c = 123.033 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION