FV STRUCTURE OF THE IGE SPE-7 IN COMPLEX WITH ACENAPHTHENEQUINONE


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B-Cell Epitope
Epitope  
   
Complex PDB ID 1OAX
Accession Number 3DIEP0216
IEDB ID 116186
Epitope Sequence acenaphthene-1;2-dione
Starting Position122
Ending Position122
Epitope Type Non peptidic

Assay Information  
Assay Antigen acenaphthene-1;2-dione
PDB CategoryIMMUNE SYSTEM
Keyword IMMUNE SYSTEM; ANTIBODY/COMPLEX; ANTIBODY; ALLERGY; IGE
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain L
Antibody Chain 2 PDB ChainH
Antigen PDB ChainH
Contact Area for Antigen 306
Contact Area for Antibody131.2
CommentsComparison of this structure with structures of the same antibody SPE7 Fv in complexes with other haptens; DNP-Ser [PDB: 1OAU]; furazolidone [PDB:1OAY]; and alizarin-red [PDB: 1OAR]; reveals that configurations of binding are very similar with only slight alterations in the positions of a few antibody side chains. Different haptens make different sets of hydrogen bonds thus mediating cross-reactivity of the antibody

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.67
R-Value
Space Group
P 21 21 21
Unit Cell
Length(Å) Angle(°)
a = 78.726 α = 90
b = 78.636 β = 90
c = 167.564 γ = 90


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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