Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A


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T-Cell Epitope
Epitope  
   
Complex PDB ID 1U3H
Accession Number 3DIEP0293
IEDB ID 89042
Epitope Sequence SRGGASQYRPSQ
Starting Position-3
Ending Position8
Epitope Type Linear Epitope

Assay Information  
Assay Antigen SRGGASQYRPSQ
PDB CategoryIMMUNE SYSTEM
Keyword complex; IMMUNE SYSTEM
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain A
Antigen PDB ChainP
CommentsEpitope-specific 172.10 TCR single-chain Fv complexed to I-Au-epitope was crystallized. There are two molecules in the crystallographic asymmetric unit. PDB chains for each complex are: Complex I: MHC ?-chain: C; MHC ?-chain: D; epitope chain: P; TCR ?-chain: A; TCR ?-chain: B. Complex II: MHC ?-chain: G; MHC ?-chain: H; epitope chain: I; TCR ?-chain: E; TCR ?-chain: F.The final model includes TCR residues: ? chain 2-116 and ? chain 3-117; MHC residues: ? chain 1-181 and ? chain 1-190 and all epitope residues.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.42
R-Value
0.232
Space Group
C 2 2 21
Unit Cell
Length(Å) Angle(°)
a = 87.835 α = 90
b = 327.162 β = 90
c = 127.161 γ = 90



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Source Information  
Structure Determination Method X-RAY DIFFRACTION