INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY


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B-Cell Epitope
Epitope  
   
Complex PDB ID 2VIR
Accession Number 3DIEP0120
IEDB ID 104697
Epitope Sequence G145; V146; T147; Q148; N149; G150; G151; S152; N153; T171; K172; S173; G174; S175; E206; S209; L210
Starting Position145-153,171-175,206,209
Ending Position210
Epitope Type Discontinuous Epitope

Assay Information  
Assay Antigen TLCLGHHAVPNGTLV KTITDDQIEVTNATE LVQSSSTGKICNNPH RILDG¦ Hemagglutinin precursor (28-328) Influenza A virus (A/X-31(H3N2))
PDB CategoryCOMPLEX (HEMAGGLUTININ/IMMMUNOGLOBULIN)
Keyword COMPLEX (HEMAGGLUTININ/IMMMUNOGLOBULIN); GLYCOPROTEIN
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain B
Antibody Chain 2 PDB ChainA
Antigen PDB ChainC
Contact Area for Antigen 612
Contact Area for Antibody651.6
CommentsEpitope is calculated from atom coordinates of the WT antigen-antibody complex structure [PDB: 2VIR]; using distance criteria cutoff at 4 Ã…. The HA protein selected corresponds to the parental strain A/Aichi/2/68 as the current SwissProt HA sequence assigned to the reassortant X-31 differs with the sequence deposited at the PDB entry.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
R-Value
Space Group
P 61 2 2
Unit Cell
Length(Å) Angle(°)
a = 85.5 α = 90
b = 85.5 β = 90
c = 515 γ = 120


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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