THREE-DIMENSIONAL STRUCTURE OF A FLUORESCEIN-FAB COMPLEX CRYSTALLIZED IN 2-METHYL-2;4-PENTANEDIOL


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B-Cell Epitope
Epitope  
   
Complex PDB ID 4FAB
Accession Number 3DIEP0146
IEDB ID 76926
Epitope Sequence fluorescein
Starting Position218
Ending Position218
Epitope Type Non peptidic

Assay Information  
Assay Antigen fluorescein
PDB CategoryIMMUNOGLOBULIN
Keyword IMMUNOGLOBULIN
Antibody Residues Interacting with Antigen Open in new window      Download dimplot pdb file
Antibody Chain 1 PDB Chain L
Antigen PDB ChainH
CommentsThe intact 4-4-20 antibody was derived from the same idiotypic family as 9-40 (see complex of 9-40 Fab with fluorescein PDB ID 1t66). These two antibodies differ by few somatic mutations in the germline genes which leads to a 1000-fold reduction in affinity for fluorescein of the 9-40 relative to 4-4-20.

Experimental Details
Method
X-RAY DIFFRACTION
Resolution
2.7
R-Value
0.215
Space Group
P 1
Unit Cell
Length(Å) Angle(°)
a = 58.3 α = 82.1
b = 43.9 β = 87.3
c = 42.5 γ = 84.6


Source Information  
Structure Determination Method X-RAY DIFFRACTION


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Ligand
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